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stone of madness

 
 
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The stone of madness, also called stone of folly, was a hypothetical stone in a patient's head, thought to be the cause of madness, idiocy or dementia. From the 15th century onwards, removing the stone by trepanation was proposed as a remedy. This procedure is demonstrated in the painting The Extraction of the Stone of Madness by Hieronymus Bosch.

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